Team

The project Consortium of two partners from Romania:

  • Coordinator from Timisoara : Romanian Academy – Timisoara Branch (AR-FT)
  • Partner no. 1 from Bucharest : University of Medicine and Pharmacy Carol Davila Bucharest (UMFCD)

Dr.ing. Sandor BERNAD, project coordinator (AR-FT)

(https://www.researchgate.net/profile/Sandor_Bernad), or (http://www.brainmap.ro/profile/Sandor-Ianos-Bernad) and (http://mh.mec.upt.ro/Index.aspx?p=staff&id=c1c65b71-60d0-4671-a5b6-eacc03cd2fb2),  Senior Researcher degree I, principal investigator, coordinator of the project, specialist in hydrodinamics of the complex fluids, Executive director of the Research Center for Engineering of Systems with Complex Fluids  in ”Politehnica” University of Timisoara (http://mh.mec.upt.ro/Index.aspx?p=Facilities). His research is focusing on the investigation and analysis of the main hemodynamics parameters (numerically and experimentally) for cardiovascular application, to diagnose and develop new therapeutic methodology for artery diseases (arterosclerosis) by the means of the Magnetic Drug Targeting in the afected artery region. Dr. Bernad has published 28 peer-reviewed journal papers, 3 books and 4 book-chapters concerning fluid dynamics, flow characterization, as well as engineering and biomedical applications of the complex flows.

Publications related to the activities of this project proposal:

  1. Sandor I. Bernad, Alin F. Totorean, Ladislau Vekas, Particles deposition induced by the magnetic field in the coronary bypass graft model, Journal of Magnetism and Magnetic Materials, 2016, vol 401, pp: 269-286, doi:10.1016/j.jmmm.2015.10.020;
  2. Sandor I. Bernad, Alin I. Bosioc, Elena S. Bernad, Marius L. Craina, Helical type coronary bypass graft performance: Experimental investigations, Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. 477-486, 2015, doi: 10.3233/BME-151337;
  3. I. Bernad, A. Bosioc, E.S. Bernad, M.L. Craina, Comparison between experimentally measured flow patterns for straigth and helical type graft, Bio-Medical Materials and Engineering, Volume 24/1, 2014, pp: 853-860, doi: 10.3233/BME-130877.
  4. Bernad Sandor, Bernad Elena, Craina Marius, Sargan Izabella, Totorean Alin, Brisan Cosmin, Particle Depositions and Related Hemodynamic Parameters in the Multiple Stenosed Right Coronary Artery, Journal of Clinical Medicine Research, vol 4, no 3, pp: 177-189, doi:10.4021/jocmr843w, (2012).
  5. Bernad, S.I., Totorean, A., Bernad, E.S., Susan-Resiga, R., Particle motion in coronary serial stenoses, WIT Transactions on Biomedicine and Health, vol 17, pp. 169-180, (2013), DOI: 10.2495/BIO130151.

Dr. Bernad has experience as a project leader of 4 multi-annual national research projects and more than 18 research contracts as project director, and as project member: in 4 international research projects and contracts, 6 multi-annual national research projects, 14 national research contracts.

Prof. Dragos VINEREANU, MD, PhD, FESC, FRCP, partner responsible (UMFCD)

(http://www.brianmap.ro/profile/Dragos-Vinereanu) is currently Vice-rector of the University of Medicine and Pharmacy Carol Davila, Bucharest, Romania, and head of the department of cardiology at the University & Emergency Hospital of Bucharest. He is also President Elect of the Romanian Society of Cardiology. He is a graduate of the University of Medicine and Pharmacy Carol Davila, Bucharest, Romania, since 1990. He has been a member of the faculty of the university since 1992. For more than 3 years he served as a clinical and research fellow in cardiology at the University of Wales College of Medicine, Cardiff, United Kingdom. His primary research interests are in echocardiography, cardiovascular risk factors, and heart failure, with a focus on tissue Doppler and deformation imaging, diagnosis of subclinical heart disease, and prevention of left ventricular dysfunction. He has been first author or co-author of more than 800 scientific presentations and more than 150 original full-papers, including papers published in New Engl J Med, Lancet, Circulation, Eur Heart J, etc. He has run or participated in 89 grants/clinical trials. He is the national coordinator and member of the Steering Committee for 12 clinical trials. He is also on the editorial board of 6 medical journals, including 2 international journals. He is member of the Romanian Academy of Medical Sciences and the secretary of the Bucharest Section of the academy. He is also Fellow of the Royall College of Physicians, Edinburgh, United Kingdom. He has received important national awards, such as the Distinguished Faculty Award of the University of Medicine and Pharmacy Carol Davila, Bucharest, the Medical Award of the Romanian Foundation for Art and Sciences of the Romanian Academy, the Award for Excellence in Cardiology of the Medic.ro Publishing House, Ministry of Health and the Romanian College of Physicians, and the Special Award “Iuliu Hatieganu” for research of the Romanian Academy.

Relevant papers and book chapters:

  1. Florescu, D. Vinereanu. Echocardiography in coronary artery bypass grafting failure. In: Coronary Graft Failure – State of the Art. Edited by: IC. Tintoiu, MJ. Underwood, SP. Cook, H. Kitabata, A. Abbas. Springer International Publishing, 2016 (in press).
  2. Badano, S. Mihaila, D. Muraru, D. Vinereanu, S. Iliceto. Functional classification of secondary mitral valve regurgitation. In: Secondary mitral regurgitation at a glance. Edited by: P. Lancellotti, K. Fattouch. Springer Science & Business media, New York, 2014: 19-28.
  3. Tatu-Chiţoiu G, Arafat R, Deleanu D, Vinereanu D, Udroiu C, Petris A. Impact of the Romanian national programme for interventional therapy in ST-elevation myocardial infarction. EuroIntervention 2012; 8 Suppl P:P126-32.
  4. Chioncel O, Ambrosy AP, Bubenek S, Filipescu D, Vinereanu D, Petris A, Christodorescu R, Macarie C, Gheorghiade M, Collins SP; the Romanian Acute Heart Failure Syndromes study investigators. Epidemiology, pathophysiology, and in-hospital management of pulmonary edema: data from the Romanian Acute Heart Failure Syndromes registry. J Cardiovasc Med (Hagerstown). 2016; 17(2): 92-104.

 Prof. Romeo SUSAN-RESIGA, (AR-FT)

(www.researchgate.net/profile/Romeo_Resiga) or (https://www.brainmap.ro/profile/Romeo-Florin-SUSAN-RESIGA) or (http://mh.mec.upt.ro/Index.aspx?p=Facilities) – is the Scientific Adviser of the project. Prof. Resiga is director of the Research Center of Engineering for Complex Fluids (http://mh.mec.upt.ro) a highly ranked research unit of the Politehnica Universty of Timisoara. He published over 72 peer reviewed articles, 7 books concerning swirling flows, mathematical modeling of fluid flow, numerical methods, flow instabilities as well as engineering and biomedical applications; he is also co-author of 2 patents in this field.

Publications related to the activities of this project proposal:

  1. Bernad, S.I., Totorean, A., Bernad, E.S., Susan-Resiga, R., Particle motion in coronary serial stenoses, WIT Transactions on Biomedicine and Health, vol 17, pp. 169-180, (2013), DOI: 10.2495/BIO130151.
  2. Bernad, S.I., Totorean, A., Bernad, E.S., Susan-Resiga, R., Flow in re-stenosed artery after angioplasty, WIT Transactions on Information and Communication Technologies, vol 45, pp. 209-220, (2013), DOI: 10.2495/DATA130191.
  3. I. Bernad, E.S. Bernad, T. Barbat, V. Albulescu, R. Susan-Resiga, Effects of different types of input waveforms in patient-specific right coronary atherosclerosis hemodynamics analysis, International Journal of Design and Nature & Ecodynamics, vol 5, no. 2, pp: 142-159, (2010).
  4. I. Bernad, T. Barbat, E.S. Bernad, R. Susan-Resiga, Numerical blood flow simulations in narrowed coronary venous bypass graft, Journal of Chinese Clinical Medicine, vol. 4, no. 1, pp: 1- 10, (2009).
  5. I. Bernad, T. Barbat, E. Bernad, R. Susan-Resiga, (2009), Computational hemodynamics analysis in realistic 3D geometries of human coronary atherosclerosis, WIT Transactions on Biomedicine and Health, Volume 13, pp: 93-102, doi: 10.2495/BIO090091.

Prof. Resiga acted as coordinator of over 7 multi-annual national and international research projects and as partner responsible of 6 national and international research projects, as well as director of over 15 international and national research contratcs.

Dr.fiz. Ladislau VÉKÁS, corresponding member of the Romanian Academy  (AR-FT)

(www.researchgate.net/profile/Ladislau_Vekas) or (http://mh.mec.upt.ro/Index.aspx?p=staff&id=af09c80f-bdc5-4044-a51d-0ab272e9ab00), corresponding member of the Romanian Academy – is the Scientific Adviser of the project. Dr. Vékás is director of the Center for Fundamental and Advanced Technical Research, a highly ranked research unit of the Romanian Academy. He published over 135 peer reviewed articles, 2 books and 6 book-chapters concerning magnetic fluids synthesis and characterization, as well as engineering and biomedical applications; he is also co-author of 14 patents in this field.

Publications related to the activities of this project proposal:

  1. Turcu Rodica, Craciunescu Izabell, Garamus Vasyl M., Janko Christina, Lyer Stefan, Tietze Rainer, Alexiou Christoph, Vekas Ladislau, Magnetic microgels for drug targeting applications: Physical-chemical properties and cytotoxicity evaluation, Journal of Magnetism and Magnetic Materials 380, 307-314, (2015);
  2. Unterweger H., Tietze R., Taccardi N., Weigel B., Lyer S., Janko C., Duerr S., Kudejova P., Wagner F. M. Petry, W., Turcu R., Tombacz E., Vekas L., Alexiou C., Boron containing magnetic nanoparticles for neutron capture therapy – an innovative approach for specifically targeting tumors, Anticancer Research 34(11)6848-6849, (2014);
  3. Savva Ioanna, Odysseos Andreani D., Evaggelou Loucas, Marinica Oana, Vasile Eugeniu, Vekas Ladislau, Sarigiannis Yiannis, Krasia-Christoforou Theodora, Fabrication, Characterization, and Evaluation in Drug Release Properties of Magnetoactive Poly(ethylene oxide)-Poly(L-lactide) Electrospun Membranes, Biomacromolecules14(12) 4436-4446, (2013);
  4. V. Avdeev, B. Mucha, Katrin Lamszus, L. Vékás, V.M. Garamus, A.V. Feoktystov, Oana Marinica, Rodica Turcu, Regine Willumeit, Structure and in vitro biological testing of water-based ferrofluids stabilized by mono-carboxylic acids, Langmuir, 26 (11) 8503-8509, (2010);

Dr. Vékás acted as responsible/coordinator of over 50 multi-annual national and international research projects.

As one of the leading scientist in the field, Dr. Vékás is member of the International Steering Committee of Magnetic Fluids and member of the European Academy of Sciences and Arts (Salzburg).

Assoc. Prof. Elena BERNAD, MD., PhD., (AR-FT)

(www.researchgate.net/profile/Elena_Bernad) – is Senior Researcher in the project, group leader of Bio-Medical applications in AR-FT team. Current position: Associate Professor at the University of Medicine and Pharmacy Victor Babes Timisoara, Head of Surgery Department at the University Clinic Bega. She has expertise in the analysis and interpretation of the numerical and experimental results of the flow field in bio-medical applications from the medical point of view. Dr. Elena Bernad focused research activities in the field of hemodynamics, blood flow in complex human geometries like arterial and feto-placental systems, particle transport and deposition in vascular systems. She has published 24 peer-reviewed international journal papers, 28 peer-reviewed international conference (24 ISI), 4 books and 8 book chapters. Dr. Elena Bernad has experience as a project director/key person over of 8 multi-annual international and national research projects.

Publications related to the activities of this project proposal:

  • Elena S. Bernad, Sandor I. Bernad, Izabella Sargan, Marius L. Craina, Saphenous vein graft patency after geometry remodeling, Journal of Mechanics in Medicine and Biology, 2015, vol. 16, no. 2, 1540051, http://dx.doi.org/10.1142/S0219519415400515,
  • S. Bernad, S.I. Bernad, M.L. Craina, Hemodynamic parameters measurements to assess severity of serial lesions in patient specific right coronary artery, Bio-Medical Materials and Engineering, 2014, Volume 24, Issue 1, pp: 323-334, DOI 10.3233/BME-130814;
  • S. Bernad, S. I. Bernad, A. F. Totorean, C. I. Hudrea, A. I. Bosioc and N. Crainic, Fluid dynamics in 45 degrees arterial by-pass model, AIP Conf. Proc., vol 1702, 080010-1-80010-4, (2015), http://dx.doi.org/10.1063/1.4938805.
  • Bernad E.S., Craina M., Bernad S.I., Blood flow simulations in patient-specific coronary bypass grafts, WIT Transactions on Information and Communication Technologies, vol 45, pp. 187-196, DOI: 10.2495/DATA130171.
  • Bernad, S.I., Bosioc, A., Totorean, A., Stanciu, R., Bernad, E.S., Vortices in By-pass Graft Flow, 11TH Internatioanl Conference of Numerical Analysis and Applied Mathematics, AIP Conference Proceedings, Volume: 1558, Pages: 160-163, 2013, DOI: 10.1063/1.4825445, 2013.

Assoc. Prof. Catalin Constantin BADIU, MD, PhD., (UMFCD)

(https://www.researchgate.net/profile/Catalin_Badiu) and (https://www.spitalulmonza.ro/medic/dr-catalin-badiu/), Senior cardiovascular surgeon and head of the department of cardiovascular surgery at the „Spitalul Universitar de Urgenta Bucuresti” is a specialist in coronary bypass surgery and valvular surgery and Co-Investigator or Principal-Inverstigator in several pre- or postmarket studies performed at the German Heart Centre Munich at the Technische Universitaet Muenchen. The doctoral thesis of Dr. Badiu at the Technische Universitaet Muenchen in 2007 was “Effect of C1-esterase inhibitor on myocardial function and area of  risk after ischemia and reperfusion in a swine model”, a topic related to the activities of this project proposal. His research is focusing on the investigation of the long-term results after different valve repair or replacement techniques. Dr. Badiu has published 41 peer-reviewed journal papers concerning different cardiovascular topics.

Publications related to the activities of this project proposal:

  1. Schreiber C, Heimisch W, Schad H, Brkic A, Badiu C, Lange R, Bauernschmitt R., C1-INH and its effect on infarct size and ventricular function in an acute pig model of infarction, cardiopulmonary bypass, and reperfusion., Thorac Cardiovasc Surg. 2006 Jun;54(4):227-32
  2. Dummler, M. Krane, M. Dressen, H. Lahm, C. Tesche, H. Hauner, S. Wildhirt, B. Voss, C.C. Badiu, R. Lange, R. Bauernschmitt,  Antiapoptotic Network May Contribute to Atherosclerotic Resistance of the Internal Thoracic Artery, Arteriosclerosis Thrombosis and Vascular Biology 29(7):E46-E47.

Dr.ing. Alin F TOTOREAN, (AR-FT)

(www.researchgate.net/profile/Alin_Totorean) or (http://mh.mec.upt.ro/Index.aspx?p=staff&id=41e8e8c1-a39b-4390-9baa-3517f6b07d66) – is Post Doc Researcher in the project. Age: 29; Current position: Assistant Professor at the Department of Medical Engineering, and Scientific Researcher at the Research Centre for Engineering of Systems with Complex Fluids,  Politehnica University of Timisoara. He received his PhD in Mechanical Engineering  in March 2016 at the Politehnica University of Timisoara. Dr. Totorean focused his research activities on the following issues: fluid dynamics, numerical analysis of flow phenomena, cardiovascular hemodynamics, cardiovascular pathology and therapy (cardiovascular bypass graft hemodynamic analysis). The results of his work were published in 6 peer-review journal papers (5 ISI ranked) and 12 international conference papers (10 ISI).

Publications related to the activities of this project proposal:

  1. I. Bernad, A.F. Totorean, L. Vekas, ”Particles deposition induced by the magnetic field in the coronary bypass graft model”, Journal of Magnetism and Magnetic Materials, vol. 401, 269-286, 2016, (IF=1,97).
  2. Alin F.Totorean, Sandor I. Bernad, Romeo F. Susan-Resiga, Fluid dynamics in helical geometries with applications for by-pass grafts, Applied Mathematics and Computation, vol 272 part 3, pp: 604-613, 2016, http://dx.doi.org/10.1016/j.amc.2015.05.030, (IF=1.551).
  3. Alin F. TOTOREAN, Alin I. BOSIOC, Sandor I. BERNAD, Romeo SUSAN-RESIGA, CRITICAL FLOW REGIONS IN THE CORONARY BY-PASS GRAFT ANASTOMOSIS, PROCEEDINGS OF THE ROMANIAN ACADEMY, Series A, 16 (2):201–208, 2015, (IF=1.658).
  4. F. Totorean, S. I. Bernad, A. Bosioc, I. C. Hudrea, E. S. Bernad and R. F. Susan-Resiga, The influence of number of turns to helicity variations at the outlet sections in helical geometries with applications for by-pass graft, AIP Conf. Proc., vol 1702, 080007-1-080007-4, (2015), http://dx.doi.org/10.1063/1.4938802.
  5. F. Totorean, A.I. Bosioc, S.I. Bernad, R. Susan-Resiga, Identification an visualization of the vortices in by-pass graft flow, PROCEEDINGS OF THE ROMANIAN ACADEMY SERIES A-MATHEMATICS PHYSICS TECHNICAL SCIENCES INFORMATION SCIENCE 15(1):52-59, 2014, (IF=1.115).

Claudia I HUDREA, MD., PhD student, (AR-FT)

(https://www.researchgate.net/profile/Iuliana_Hudrea). PhD Student at Victor Babes University of Medicine and Pharmacy, Timisoara, and Cardiology Resident at the Institute of Cardiovascular and Heart Diseases, Timisoara. Her research is focusing on the analysis of coronary stent restenosis and thrombosis from a haemodynamic perspective. Dr. Hudrea has published 1 peer-review journal paper (ISI ranked) and 5 international conference papers (ISI).

Publications related to the activities of this project proposal:

1.Totorean AF, Hudrea IC, Bosioc AI, Bernad SI, Flow field evolution in stented versus stenosed coronary artery, Proceedings of the Romanian Academy – Series A- Mathematics Physics Technical Sciences Information Science, 2017, Vol. 18 (3), p. 248-255 (WOS:000411046400008)(IF=1.623)

  1. Totorean AF, Bernad SI, Hudrea IC, Susan-Resiga RF, Competitive flow and anastomosis angle influence on bypass hemodynamics in unsteady flow conditions, International Conference of Numerical Analysis and Applied Mathematics 2016 (ICNAAM 2016), 19-25 September 2016, Rhodes, Greece, ISBN: 978-0-7354-1392-4, AIP Conference Proceed6ings 1863, 030013-1 (2017); (WOS:000410159800019).
  2. E. S. Bernad, I.C. Hudrea, S. I. Bernad, A. F. Totorean, A. I. Bosioc, Luminal flow alteration in presence of the stent, AIP Conf. Proc., vol 1702, 080011-1-080011-4, (2015), http://dx.doi.org/10.1063/1.4938806, ISBN: 978-0-7354-1349-8, (WOS:000371804300037)
  3. S. I. Bernad, A. Totorean, A. Bosioc, N. Crainic, I.C. Hudrea, E. S. Bernad, Fluid mechanics in stented arterial model, AIP Conf. Proc., vol 1702, 080008-1–080008-4, (2015), http://dx.doi.org/10.1063/1.4938803, ISBN: 978-0-7354-1349-8, (WOS:000371804300034)
  4. A. F. Totorean, S. I. Bernad, A. Bosioc, I.C. Hudrea, E. S. Bernad and R. F. Susan-Resiga, The influence of number of turns to helicity variations at the outlet sections in helical geometries with applications for by-pass graft, AIP Conf. Proc, vol 1702, 080007-1-080007-4, (2015), http://dx.doi.org/10.1063/1.4938802, ISBN: 978-0-7354-1349-8, (WOS: 000371804300033).

Alexandru George COTOBAN, MD., PhD student, (UMFCD)

Assistant Professor in Cardiology at the University of Medicine and Pharmacy Carol Davila, Bucharest, and Cardiology Registrar at the University and Emergency Hospital Bucharest. His research is focusing on the quality of care received by patients presenting with acute non-ST elevation acute coronary syndromes in Romania. Dr. Cotoban has published 7 abstracts or full text papers on the complex management (interventional and surgical) of patients presenting with complex ST and non-ST elevation myocardial infarction, cardiogenic shock, and myocarditis.

Publications related to the activities of this project proposal:

  1. Cotoban AG, Udroiu C, Vinereanu D. Acute ST-elevation myocardial infarction in a patient with prolonged resuscitation. Rom J Cardiol 2015; Supplement: 81-83.
  2. Udroiu C, Cotoban AG, Ursulescu A, Siliste C, Vinereanu D. Interdisciplinary Approach in a Complex Case of STEMI. Maedica – a Journal of Clinical Medicine 2014; 9(4): 382-386.
  3. Udroiu C, Cotoban AG, Ursulescu A, Vinereanu D. STEMI with multiple complications: favorable long-term outcome by combining surgical and interventional treatment. Rom J Cardiol 2013; Supplement B: B132-133.

Dr. Cotoban has experience as target group assistant in one national training programme of PhD students in the field of research.

Mr. George GIULA assistant researcher, (AR-FT)

Main activities and responsibilities

  • technical applications of magnetic fluids and magnetorheological suspensions (rotating seals, transducers, sensors, dampers);
  • participation at research projects;
  • documentation in the filed of activit