Project team previous results

Numerical and experimental investigations

Project Preliminary results (numerical simulations of the flow in different artery disease, experimental results regarding particle targeting in biomedical applications) available prior the project application.

      For example, results regarding PEG-coated nanocluster targeting around the stent model generated the primary question regarding cluster agglomeration in a magnetic field in the investigated artery segment.

      Also, preliminary results for rheological and magnetical characterization of nanoparticles.             Numerical simulation of the magnetic field distribution in the targeted region.

Numerical and in vitro investigations of the different stent type performances

Preliminary results (numerical simulations of the flow in different artery disease, numerical investigation of the mechanical performances of the developed magnetic stent) available prior the project application. Most important preliminary results of cytotoxicity test both for magnetic stent and PEG-coated nanoparticles. Also, investigation of the magnetic cell captures to intracoronary stents in a large animal model.

MNP synthesis and characterization

Preliminary results (synthesis and characterization of several types of nanomagnetic particle coated with PLGA or PEG for biomedical applications. Also, physico-chemical characterization of the of different type of nanoparticles and nanocomposites coated with PEG.

The preliminary results obtained and published before the present project proposal by the project team, in the form of articles in ISI quoted journals, in international and national patents, and the form of results obtained in several multi-annual projects (led by the members of the project team) is the starting point of this project. The efforts made to find acceptable solutions for the treatment of vascular disease, was facilitated the obtaining of valuable information regarding (i) to the blood hemodynamics for both the vascular pathology and the different medical treatments used; (ii) the synthesis and complex chemical-physical characterisation of the different coated magnetic particles intended for biomedical applications.

Figures presents the synthesis of the main results obtained by the project members in the theme of the present project proposal.

References

Team members publication regarding to the project – examples (team members in blue)

 

  1. Sandor I. Bernad, Izabell Craciunescu, Gurpreet S. Sandhu, Dan Dragomir-Daescu, Etelka Tombacz, Ladislau Vekas, Rodica Turcu, Fluid Targeted delivery of functionalized magnetoresponsive nanocomposite particles to a ferromagnetic stent, J of Mag and Magn Mat, 519, 167489, 2020.
  2. Sandor I. Bernad, Daniela Susan-Resiga, Elena Bernad,  Hemodynamic Effects on Particle Targeting in the Arterial Bifurcation for Different Magnet Positions, MOLECULES, Volume: 24(13), 2509, (2019).
  3. SI Bernad, D Susan-Resiga, L Vekas, ES Bernad, Drug targeting investigation in the critical region of the arterial bypass graft Journal of Magnetism and Magnetic Materials, 475, 14-23 (2019).
  4. Sandor I. Bernad, Alin F. Totorean, Ladislau Vekas, Particle deposition induced by the magnetic field in the coronary bypass graft model, J. Magn. Magn. Mater., 401, pp: 269–286 (2016).
  5. Uthamaraj S, Tefft BJ, Hlimonaz O, Klabusay M, Sandhu GS, Dragomir-Daescu D. Design and validation of a novel ferromagnetic bare metal stent capable of capturing and retaining endothelial cells, Annals of Biomedical Engineering. 2014 Aug 20; 42(12):2416-2424.
  6. J. Tefft, S. Uthamaraj, A. Harbuzariu, J.J. Harburn, T.A. Witt, B. Newman, P.J Psaltis, O. Hlinomaz, D.R. Holmes Jr, R. Gulati, R.D. Simari, D. Dragomir-Daescu, G.S. Sandhu, Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent, Tissue Eng Part A. 2018 Jul;24(13-14):1157-1166.
  7. Socoliuc, V; Turcu, R: “Large scale aggregation in magnetic colloids induced by high frequency magnetic fields”, JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 500, (2020), 166348(pp.6).
  8. Papaparaskeva, G, Dinev, MM,Krasia-Christoforou, T , Turcu, R, Porav, SA, Balanean F, Socoliuc, V., White Magnetic Paper with Zero Remanence Based on Electrospun Cellulose Microfibers Doped with Iron Oxide Nanoparticles, NANOMATERIALS, 10 (3), Article Number: 517, 2020.
  9. Illés, M. Szekeres, E. Kupcsik, I.Y. Tóth, K. Farkas, A. Jedlovszky-Hajdú, E. Tombácz, PEGylation of surfacted magnetite core-shell nanoparticles for biomedical application, Colloids and Surfaces A, 2014, 460:429-440.
  10. Illes, E; Szekeres, M; Toth, IY; Szabo, A; Ivan, B; Turcu, R; Vekas, L; Zupko, I; Jaics, G; Tombacz, E, Multifunctional PEG-carboxylate copolymer coated superparamagnetic iron oxide nanoparticles for biomedical application, Journal of Magnetism and Magnetic Materials, 451, 710-720 (2018).
  11. Bunge, A.S. Porav, G. Borodi, T. Radu, A. Pîrnău, C. Berghian-Grosan, R. Turcu, Correlation between synthesis parameters and properties of magnetite clusters prepared by solvothermal polyol method, Journal of Materials Science 54(4), 2853-2875 (2019).
  12. Turcu, V. Socoliuc, I. Craciunescu, A. Petran, A. Paulus, M. Franzreb, E. and L. Vekas, Magnetic microgels, a promising candidate for enhanced magnetic adsorbent particles in bioseparation: synthesis, physicochemical characterization, and separation performance, Soft Matter, 2015, 11, 1008–1018.
  13. Petran, T. Radu, A. Nan, D. Olteanu, A. Filip, S. Clichici, I. Baldea, M. Suciu, R. Turcu, Synthesis, characterization and cytotoxicity evaluation of high magnetization multifunctional nanoclusters, Journal of Nanoparticles Research, Vol. 19(1), article 10, 2017.
  14. Nan, T. Radu, R. Turcu, Poly(glycidyl/methacrylate) functionalized magnetic nanoparticles as platforms for linking functionalities, bioentities and organocatalysts, RSC-Advances 6, 43330-43338, (2016).
  15. Borbáth, I. Borbáth, Dmitry Yu B., Günther S., Vékás L., Odenbach S., Three-dimensional microstructural investigation of high magnetization nano-micro composite fluids using X-ray microcomputed tomography, Smart Materials and Structures, 23 (5), 055018, (2014).
  16. Susan-Resiga D., Socoliuc V., Boros T., Borbáth T., Marinica O., Han A., Vékás L., The influence of particle clustering on the rheological properties of highly concentrated magnetic nanofluids, Journal of Colloid and Interface Science 373, p. 110–115, (2012).

Previous PROJECTS correlated with the present proposal – examples (team members in blue)

 

  1. “Innovative nature of the Helical-type Artery Bypass Graft”, (2017-2018), Romanian R&D Program PN-III-P2-2.1-PED-2016-0293, TRL4 demonstrator project (ARFT (CO) – Bernad S. – PI).
  2. “Fundamental research regarding the aspects associated to the blood flow in the pathology of the human circulatory system with quantification of their implications on the placental circulation” (2009-2011), Romanian R&D Program, Project ID:PN-II-ID-2008-2, Contract no.658/2009 (ARFT, Bernad S.- PI).
  3. “Nanostructured biocompatible systems based on magnetic nanoparticles and stimuli responsive polymers” (2007-2010), PN2 Partnership in priority fields, Romanian R&D Program, contract 71-068/2007 (INCDTIM – partner, INCDTIM responsible – R. Turcu).
  4. “Advanced Magnetic nanoparticles deliver smart Processes and Products for Life” – MagPro²Life Nr. 229335, (2009-2013), financed by European Union, Collaborative project, Large-scale integrating project, Seventh Framework Program FP7-NMP-2008-LARGE 2 – (ARFT and INCDTIM partners, ARFT responsible L. Vekas, INCDTIM responsible R. Turcu).
  5. RMM-2017-BB-02 (Regenerative Medicine Minnesota): Dragomir-Daescu (PI), 2017-2018, Controllable and automated system for synthesizing GMP magnetic nanoparticles for regenerative medicine application.
  6. COST project: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy. COST Action RADIOMAG, TD1402 (2014-2018), (ARFT, INCDTIM, Univ. of Szeged, partners, ARFT responsible L. Vekas, INCDTIM responsible R. Turcu, Univ. of Szeged responsible E. Tombacz).

 

Team members PATENTS in the field of the present proposal – examples (team members in blue)

 

  1. RO127622, Nan, R. Turcu, J. Liebscher, Method for the preparation of iron oxide nanoparticles.
  2. Sandhu GS, Dragomir-Daescu D, Rihal CS, Asirvatham SJ, inventors. Mayo Foundation for Medical Education and Research, assignee. Conformable Stents and Methods for Making, US patent 8,388,674 B2, Japan patent JP 2010-547862, WO patent application #2009/108699.
  3. RO133612(A0)-2019-09-30, Process for preparng magnetic clusters with high magnetization, based on magnetite nanoparticles and feco/aloparticles, Autors: Crăciunescu Izabell, Turcu Rodica Paula, Balanean Florica, Vekas Ladislau.
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